Chronic diarrhoea lasting more than four weeks needs systematic investigation, not just antidiarrhoeal medication. Book a consultation with Dr. Chhavi Bansal today.
How Diarrhoea Works
Normal stool is around 75 percent water. Diarrhoea occurs when water content rises above that threshold, either because the gut is secreting excess water, because something in the gut is drawing water in osmotically, because the gut is moving contents too fast to absorb water normally, or because gut lining damage is preventing proper absorption.
In secretory diarrhoea, the gut epithelium actively secretes chloride and sodium, drawing water with it. This happens with certain bacterial toxins (cholera is the extreme example), with bile acid malabsorption, and with some hormonal tumours. In osmotic diarrhoea, unabsorbed substances in the gut draw water in by osmosis. Lactose reaching the colon undigested is a classic example. In motility-driven diarrhoea, the gut propels contents too fast, which is common in IBS-D and hyperthyroidism.
Warning Signs That Require Prompt Investigation
The Missed Causes Checklist
Standard IBS-D management misses several conditions that cause chronic diarrhoea. Microscopic colitis (collagenous or lymphocytic colitis) is invisible on routine colonoscopy but shows up on biopsy. Bile acid malabsorption is never diagnosed without specific testing. Giardia in chronic low-grade infection is missed without antigen testing. Coeliac disease presents with diarrhoea and weight loss and is still routinely missed without serology. Each of these has a specific treatment that works, but you can't treat what you haven't identified.
- Microscopic colitis (requires biopsy, not just colonoscopy)
- Bile acid malabsorption (requires SeHCAT or specific blood test)
- Chronic giardia infection (requires antigen test, not just stool exam)
- Coeliac disease (requires anti-tTG IgA serology)
- Lactose intolerance driving loose stools
- Hyperthyroidism (thyroid function not always checked in diarrhoea workup)
- SIBO with diarrhoea-predominant pattern